Riociguat (BAY 63-2521) Duty

Riociguat (BAY 63-2521) DutyRiociguat (BAY 63 2521) is an oral soluble guanylate cyclase (GC) stimulator, used in the treatment of ipulmonary hypertension.

JNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays

abemaciclib (LY2835219) is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays

Tivozanib (AV-951) is a potent and selective VEGFR inhibitor for VEGFR1/2/3 with IC50 of 30 nM/6

Parecoxib is a selective COX2 inhibitor

reversible AMPK activator with EC50 of 0

displays less potent inhibiton over PKA

4-Diaminobutane is used as a precursor in many biological systems and synthon for amido-ureas

2-receptor agonist

Assorted Colors - COP

and the heart that protects cells against oxidative stress

JNJ-26854165 (Serdemetan) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells

Morin hydrate(Aurantica) is a flavonoid isolated from Maclura pomifera (Osage orange)