PK11007 Erlenmeyer

PK11007 ErlenmeyerPK11007 is an anti p53 drug that stabilizes wild type and mutant p53 via selective alkylation of two surface exposed cysteines without compromising its DNA binding activity. It exerts antitumor functions not only via reactivating p53 but also via other cellular mechanisms, such as increase of cellular ROS to toxic levels and activation of the UPR.

Erythromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits and inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins

targets pleckstrin homology domain of Akt

Kartogenin is an activator of the smad4/smad5 pathway

-arrestin assay

Approximate dish bottom diameter and height is 95x22mm

3 nM and 197

B kinase pathway

Corning 384 well Black Tissue Culture Treated Microplate

Corning These 100mL PYREX® graduated cylinders are calibrated “to contain” (TC)

CDK1 and Erk2

M in yeast

Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation